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THE CALKINS LABORATORY Mechanisms and Therapies in Visual Science

© The Calkins Laboratory † Dr. David J. Calkins, Ph.D. † Dept. Of Ophthalmology & Visual Sciences † Vanderbilt University School of Medicine †

PUBLICATIONS

McGrady NR, Risner ML, Vest V, Calkins DJ. TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma Front. Physiol. March 2020

Risner ML, McGrady NR, Pasini S, Lambert WS, Calkins DJ. Elevated Ocular Pressure Reduces Voltage-Gated Sodium Channel NaV1.2 Protein Expression in Retinal Ganglion Cell Axons. Exp Eye Res. 2020 Jan; 190:107873

Kubota R, Calkins DJ, Henry SH, Linsenmeier RA. Emixustat Reduces Metabolic Demand of Dark Activity in the Retina. Invest Opthalmol Vis Sci. 2019 Nov 1;60(14):4924-4930

Lambert WS, Carlson BJ, Ghose P, Vest VD, Yao V, Calkins DJ. Towards a Microbead Occlusion Model of Glaucoma for a Non-Human Primate. Sci Rep. 2019 Aug 9;9(1);11572

Risner ML, Pasini S, Cooper ML, Lambert WS, Calkins DJ.  Axogenic Mechanism Enhances Retinal Ganglion Cell Excitability During Early Progression in Glaucoma. Proc Natl Acad Sci U S A. 2018, Mar 6;115(10):E2393-E2402

Laughter Melissa R, Bardill James R, Ammar David A, Pena Brisa, Calkins David J, Park Daewon. Injectable Neurotrophic Factor Delivery System Supporting Retinal Ganglion Cell Survival and Regeneration Following Optic Nerve Crush. ACS Biomater. Sci. Eng. 2018, 4, 3374-3383

Bernardo-Colón Alexandra, Vest Victoria, Clark Adrienne, Cooper Melissa L, Calkins David J, Harrison Fiona E, Rex Tonia S. Antioxidants Prevent Inflammation and Preserve the Optic Projection and Visual Function in Experimental Neurotrauma. Cell Death and Disease. 2018, 9:1097

Cooper ML, Collyer JW, Calkins DJ. Astrocyte Remodeling Without Gliosis Precedes Optic Nerve Axonopathy. Acta Neuropathol Commun, May 2018

Risner ML, Pasini S, Cooper ML, Lambert WS, Calkins DJ.  Axogenic Mechanism Enhances Retinal Ganglion Cell Excitability During Early Progression in Glaucoma.  Proc Natl Acad Sci USA, February 2018 (supporting information)

Anderson DMG, Lambert W, Calkins DJ, Ablonczy Z, Crouch RK, Caprioli RM, Schey KL.  Imaging MS of Rodent Ocular Tissues and the Optic Nerve.  Methods in Molecular Biology, May 2017

Lambert WS, Carlson BJ, Formichella CR, Sappington RM, Ahlem C, Calkins DJ. Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma. Frontiers in Neuroscience, February 2017

Calkins DJ, Pekny M, Cooper ML, Benowitz L, group The Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants. The Challenge of Regenerative Therapies for the Optic Nerve in Glaucoma. Experimental Eye Research, January 2017

Breen KT, Anderson SR, Steele MR, Calkins DJ, Bosco A, Vetter ML. Loss of Fractalkine Signaling Exacerbates Axon Transport Dysfunction in a Chronic Model of Glaucoma. Frontiers of Neuroscience, November 2016

Bosco A, Breen KT, Anderson SR, Steele MR, Calkins DJ, Vetter ML. Glial Coverage in the Optic Nerve Expands in Proportion to Optic Axon Loss in Chronic Mouse Glaucoma. Experimental Eye Research, February 2016.

Bond WS, Hines-Beard J, GoldenMerry YPL, Davis M, Farooque A, Sappington RM, Calkins DJ, Rex TS. Virus-Mediated EpoT76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma. Molecular Therapy, February 2015.

Cooper ML, Crish SD, Inman DM, Horner PJ, Calkins DJ. Early Astrocyte Redistribution in the Optic Nerve Precedes Axonopathy in the DBA/2J Mouse Model of Glaucoma. Experimental Eye Research, December 2015.

Crish SD, Calkins DJ. Central Visual Pathways in Glaucoma: Evidence for Distal Mechanisms of Neuronal Self-Repair. Journal of Neuro-Ophthalmology, September 2015.

Sappington RM, Sidorova T, Ward NJ, Chakravarthy R, Ho KW, Calkins DJ. Activation of Transient Receptor Potential Vanilloid-1 (TRPV1) Influences How Retinal Ganglion Cell Neurons Respond to Pressure-Related Stress. Channels, 2015.

Lambert WS, Carlson BJ, van der Ende AE, Shih G, Dobish JN, Calkins DJ, Harth E. Nanosponge-Mediated Drug Delivery Lowers Intraocular Pressure. Translational Vision Science & Technology,  January 13 2015.

Weitlauf C, Ward NJ, Lambert WS, Sidorova TN, Ho KW, Sappington RM, Calkins DJ. Short-Term Increases in Transient Receptor Potential Vanilloid-1 Mediate Stress-Induced Enhancement of Neuronal Excitation. The Journal of Neuroscience, November 12, 2014.

Ho KW, Lambert WS, Calkins DJ. Activation of the TRPV1 Cation Channel Contributes to Stress-Induced Astrocyte Migration. Glia, September 2014.

Ward NJ, Ho KW, Lambert WS, Weitlauf C, Calkins DJ. Absence of Transient Receptor Potential Vanilloid-1 Accelerates Stress-Induced Axonopathy in the Optic Projection. The Journal of Neuroscience, February 26, 2014.

Calkins DJ. Age-Related Changes in the Visual Pathways: Blame it on the Axon. Investigative Ophthalmology & Visual Science, December 13, 2013.

Dapper JD, Crish SD, Pang IH, Calkins DJ. Proximal Inhibition of p38 MAPK Stress Signaling Prevents Distal Axonopathy. Neurobiology of Disease, November 2013.

Inman DM, Lambert WS, Calkins DJ, Horner PJ. alpha-Lipoic Acid Antioxidant Treatment Limits Glaucoma-Related Retinal Ganglion Cell Death and Dysfunction. PloS one, June 5, 2013.

Anderson DM, Mills D, Spraggins J, Lambert WS, Calkins DJ, Schey KL. High-Resolution Matrix-Assisted Laser Desorption Ionization-Imaging Mass Spectrometry of Lipids in Rodent Optic Nerve Tissue. Molecular Vision, 2013.

Crish SD, Dapper JD, MacNamee SE, Balaram P, Sidorova TN, Lambert WS, Calkins DJ. Failure of Axonal Transport Induces a Spatially Coincident Increase in Astrocyte BDNF Prior to Synapse Loss in a Central Target. Neuroscience, January 15, 2013.

Bosco A, Crish SD, Steele MR, Romero CO, Inman DM, Horner PJ, Calkins DJ, Vetter ML. Early Reduction of Microglia Activation by Irridation in a Model of Chronic Glaucoma. PloS One 2012.

Calkins DJ. Critical Pathogenic Events Underlying Progression of Neurodegeneration in Glaucoma. Progress in Retinal and Eye Research, November 2012.

Ho KW, Ward NJ, Calkins DJ. TRPV1: A Stress Response Protein in the Central Nervous System. American Journal of Neurodegenerative Disease, 2012.

Shih GC, Calkins DJ. Secondary Neuroprotective Effects of Hypotensive Drugs and Potential Mechanisms of Action. Expert Review of Ophthalmology, April 2012.

Calkins DJ, Horner PJ. The Cell and Molecular Biology of Glaucoma: Axonopathy and the Brain. Investigative Ophthalmology & Visual Science, May 4, 2012.

Crish SD, Calkins DJ. Neurodegeneration in Glaucoma: Progression and Calcium-Dependent Intracellular Mechanisms. Neuroscience March 10, 2011.

Lambert WS, Ruiz L, Crish SD, Wheeler LA, Calkins DJ. Brimonidine Prevents Axonal and Somatic Degeneration of Retinal Ganglion Cell Neurons. Molecular Neurodegeneration, January 13, 2011.

Baltan S, Inman DM, Danilov CA, Morrison RS, Calkins DJ, Horner PJ. Metabolic Vulnerability Disposes Retinal Ganglion Cell Axons to Dysfunction in a Model of Glaucomatous Degeneration. Journal of Neuroscience, April 21, 2010.

Crish SD, Sappington RM, Inman DM, Horner PJ, Calkins DJ. Distal Axonopathy with Structural Persistence in Glaucomatous Neurodegeneration. Proc Natl Acad Sci USA, March 16, 2010.

Sappington RM, Carlson BJ, Crish SD, Calkins DJ. The Microbead Occlusion Model: A Paradigm for Induced Ocular Hypertension in Rats and Mice. Investigative Ophthalmology & Visual Science, January 2010.

Sappington RM, Sidorova T, Long DJ, Calkins DJ. TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca2+ with Exposure to Hydrostatic Pressure. Investigative Ophthalmology & Visual Science, February 2009.

Wax MB, Tezel G, Yang J, Peng G, Patil RV, Agarwal N, Sappington RM, Calkins DJ. Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cell Neurons via Activated T-cell-derived Fas-Ligand. Journal of Neuroscience, November 12, 2008.

Calkins DJ, Horner PJ, Roberts R, Gradianu M, Berkowitz BA.  Manganese-Enhanced MRI of the DBA/2J Mouse Model of Hereditary Glaucoma. Investigative Ophthalmology & Visual Science, November 2008.

Sappington RM, Calkins DJ. Contribution of TRPV1 to Microglia-Derived IL-6 and NfkappaB Translocation with Elevated Hydrostatic Pressure. Investigative Ophthalmology &Visual Science, July 2008.

Bosco A, Inman DM, Steele MR, Wu G, Soto I, Marash-Armstrong N, Hubbard WC, Calkins DJ, Horner PJ, Vetter ML. Reduced Retina Microglial Activation and Improved Optic Nerve Integrity with Minocycline Treatment in the DBA/2J Mouse Model of Glaucoma. Investigative Ophthalmology & Visual Science, April 2008.

Buckingham BP, Inman DM, Lambert W, Oglesby E, Calkins DJ, Steele MR, Vetter ML, Marsh-Armstrong N, Horner PJ. Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma. Journal of Neuroscience, March 12, 2008.

Hanna MC, Calkins DJ. Expression of Genes Encoding Glutamate Receptors and Transporters in Rod and Cone Bipolar Cells of the Primate Retina Determined by Single-Cell Polymerase Chain Reaction. Molecular Vision, November 28, 2007.

Berkowitz BA, Roberts R, Luan H, Bissig D, Bui BV, Gradianu M, Calkins DJ, Vingrys AJ. Manganese-Enhanced MRI Studies of Alterations of Intraretinal Ion Demand in Models of Ocular Injury. Investigative Ophthalmology & Visual Science, August 2007.

Calkins DJ, Sterling P. Microcircuitry for Two Types of Achromatic Ganglion Cell in Primate Fovea. Journal of Neuroscience, March 7, 2007.

DiLoreto DA Jr, Luo C, Calkins DJ, del Cerro M. An Ultrastructural Study of the Pathology of the Retinal Pigment Epithelium. Bruch’s Membrane, and the Choriocapillaris in the Aged Fischer 344 Rat. Current Eye Research, September 2006.

Sappington RM, Calkins DJ. Pressure-Induced Regulation of IL-6 in Retinal Glial Cells: Involvement of the Ubiquitin/Proteasome Pathway and Nfkappab. Investigative Ophthalmology & Visual Science, September 2006.

Hanna MC, Calkins DJ. Expression and Sequences of Genes Encoding Glutamate Receptors and Transporters in Primate Retina Determiend Using 3’-end Amplification Polymerase Chain Reaction. Molecular Vision, August 17, 2006.

Sappington RM, Chan M, Calkins DJ. Interleukin-6 Protects Retinal Ganglion Cells from Pressure-Induced Death. Investigative Ophthalmology & Visual Science, July 2006.

Inam DM, Sappington RM, Horner PJ, Calkins DJ. Quantitative Correlation of Optic Nerve Pathology with Ocular Pressure and Corneal Thickness in the DBA/2 Mouse Model of Glaucoma. Investigative Ophthalmology & Visual Science, March 2006.

Steele MR, Inman DM, Calkins DJ, Horner PJ, Vetter ML. Microarray Analysis of Retinal Gene Expression in the DBA/2J Model of Glaucoma. Investigative Ophthalmology & Visual Science, March 2006.

Calkins DJ. Localization of Ionotropic Glutamate Receptors to Invaginating Dendrites at the Cone Synapse in Primate Retina. Visual Neuroscience, July 2005.

Calkins DJ. Remembering Bob Rodieck: 1937-2003. Visual Neuroscience, July 2005.

Wilon JD, Bigelow CE, Calkins DJ, Foster TH. Light Scattering from Intact Cells Reports Oxidative-Stress-Induced Mitochondrial Swelling. Visual Neuroscience, April 2005.

Calkins DJ, Sappington RM, Hendry SH. Morphological Identification of Ganglion Cells Expressing the Alpha Subunit of Type II Calmodulin-Dependent Protein Kinase in Macaque Retina. Journal of Comparative Neurology, January 10, 2005.

Sappington RM, Pearce DA, Calkins DJ. Optic Nerve Degeneration in a Murine Model of Juvenile Ceroid Lipofuscinosis. Investigative Ophthalmology & Visual Science, September 2003.

Harvey DM, Calkins DJ. Localization of Kainate Receptors to the Presynaptic Active Zone of the Rod Photoreceptor in Primate Retina. Visual Neuroscience, September 2002.

Yao PJ, Coleman PD, Calkins DJ. High-Resolution Localization of Clathrin Assembly Protein AP 180 in the Presynaptic Terminals of Mammalian Neurons. Journal of Comparative Neurology, May 27, 2002.

Calkins DJ. Seeing with S Cones. Progress in Retinal and Eye Research, May 2001.

Calkins DJ. Representation of Cone Signals in the Primate Retina. J Opt Soc Am a Opt Image Sci Vis, March 2000.