HONS 182 Neuroethics – Fall 2007

December 4, 2007


SCHEDULE


1.         The new field of neuroethics

           a.         William Safire is credited with coining the term neuroethics.

           b.         We will use this book

           c.         We will start by discussing this paper 

           d.          For those who are interested, here are some other resources

2.         Mind-brain relations

            a.         Basics of brain function

                        Neuroscience. by Purves, Dale; Augustine, George J.; Fitzpatrick, David; Katz, Lawrence C.; LaMantia, Anthony-Samuel; McNamara, James O.; Williams, S. Mark Sunderland (MA): Sinauer Associates, Inc.; 2001.

            b.         Linking mental and neural function
i.          Outline on the brain and volition

                        ii.         Tom Wolfe, Sorry, But Your Soul Just Died

                        iii.        Schall JD. On building a bridge between brain and behavior. Annu Rev Psychol. 2004;55:23-50.

                        iv.        Where am I?  From Brainstorms:  Philosophical Essays on Mind and Psychology, Daniel C. Dennett, © Bradford Books (1978)

            c.         Decision making

                        i.         Schall JD. Decision making. Current Biology  2005. 15:R9-R11.

                        ii.        Schall JD. Neural basis of deciding, choosing and acting. Nat Rev Neurosci. 2001 Jan;2(1):33-42.

            d.         Free will
i.         Is God a Taoist By Raymond Smullyan, 1977

                        ii.        Free will on Wikipedia

            e.         Neuroscience at Vanderbilt
                               Center for Integrative & Cognitive Neuroscience
                                        
Center for Molecular Neuroscience
                                         
Psychological Sciences

                               Vanderbilt Vision Research Center
                               Vanderbilt Brain Institute
                              
Vanderbilt Kennedy Center for Research on Human Development
                               Vanderbilt University Institute of Imaging Science
                              

3.         Mental Illness
a.    History & definitions

History of Mental Illness presentation

The Tenant. Madnesse.

There is a double madnesse, corporall and spirituall, The obiect of the former is Reason: of the latter, Religion. That obsesseth the braine, this the Heart. That expects the helpe of the naturall Physitian, this of the Mysticall. The difference is; this spirituall madnesse may insanire cum ratione, cum Religione numquam. The morally-franticke may be mad with reason, neuer with Religion.

Physitians haue put a difference betwixt Phrenzy, and Madnesse: imagining madnesse to be onely an infection and perturbation of the formost Cell of the head; whereby Imagination is hurt: but the Phrenzy to extend further, euen to offend the reason and memory; 35 and is neuer without a feuer. Galen cals it an inflammation of the braines, or filmes thereof, mixed with a sharpe feuer. My purpose needes me not to be curious of this distinction.

To vnderstand the force of madnesse, we must conceiue in the brayne three ventricles; as houses assign'd by Physitians for three dwellers, Imagination, Reason, and Memorie. According to these three internal senses or faculties, there be three kinds of Phrensies or Madnesses.

1. There are some mad, that can rightly iudge of the things they see, as touching imagination & phantasie: but for cogitation and reason, they swarue from naturall iudgement.

2. Some being madde, are not deceiu'd so much in common cogitation and reason; but they erre in Phantasie and Imagination.

3 There are some, that be hurt in both imagination and reason, and they necessarily therewithall doe lose their memories. That whereas in perfect, sober, and well composed men, Imagination first conceiues the formes of things, and presents them to the reason to iudge; and reason discerning them, commits them to Memorie to retaine: in mad-men nothing is conceiu'd aright, therefore nothing deriu'd, nothing retayn'd.

For spirituall relation, we may conceiue in the soule; vnderstanding, reason, will. 1. The vnderstanding apprehendeth things according to their right natures. 2. The Reason discusseth them, arguing their fitnesse or inconuenience, validity or vanity: and examines their desert of probation or disallowance, their worthinesse eyther to be receyued or reiected. 3. The Will hath her particular working, and embraceth, or refuseth the obiects, which the vnderstanding hath propounded, & the reason discoursed.

36 Spirituall madnesse is a deprauation, or almost depriuation of all these faculties, quoad coelestia; so farre as they extend to heauenly things. 1. For vnderstanding, the Apostle sayth. [Note: 1. Cor. 2. 14. ] The naturall man perceyues not spirituall things, because they are spiritually discerned. And the very [Note: 2. Cor. 4. 4. ] minds of vnbeleeuers are blinded by the god of this world. 2. For Reason: it iudgeth vanities more worthy, of prosecution when they are absent, of embracing when they salute vs. [Note: Malac. 3. 14. ] It is in vaine to serue the Lord: and what profite is it, that wee haue kept his ordinance, or walked mournefully before him? This is the voyce of distracted cogitation, and of reason out of the wits. [Note: Vet. 15. ] Wee call the proud happy; and the workers of wickednesse are set vp: yea they that tempt God are deliuered. 3. For Will; it hath lost the propensenesse to good, and freedome of disposing it selfe to well doing: neyther hath it any power of it owne, to stoppe and retarde the precipitation to euill.

As corporall madnesse drawes a thicke obfuscation ouer these lights, so spirituall corrupts and peruerts them: that as they are strangers to heauen, quoad intellectum, so at last, they become fooles in natural things, quoad rationem. [Note: Rom. 1. 28. ] As the Apostle plainely. Euen as they did not like to retaine God in their knowledge, so God gaue them ouer to a reprobate mind, to doe those things that are not conuenient. They that forget God, shall forget nature. Hence ensue both these frenzies, and with them a dissimilitude to men, to Christian men. It is reckoned vp among the curses, that wayte on the heeles of disobedience. Deut. 28. [Note: Deut. 28. 28. ] The Lord shall smite thee with madnesse, blindnesse, and astonishment of heart. But it is a fearefull accumulation of Gods iudgements and our miseries, when spirituall Phrensie shall possesse the soule, and scatter the powers of the inner man: euacuating not onely imagination; but knowledge; not reason, but faith; not sense, but conscience. When the opinion of the world shall repute men sober and wise, and the scrutinie of God shall finde them mad-men.

20. Lastly,

To omit our Schismatickes, and Separatists, who are truly called, Protestants out of their wittes, lyable to the imputation of Phrenzy: the Papists are certainely madmen, dangerous mad-men; madde in themselues, dangerous to vs: and would happily be confined to some locall Bedlam, lest their spirituall lunacy doe vs some hurt.

Madde in themselues: for who but mad-men would forsake the fountaine of liuing waters, [Note: Ier. 2. 13. ] the word of truth, and pinne their faith and saluation on the Popes sleeue? a Prelate, [Note: Luk. 13. 1. ] a Pilate, that mingles their owne bloud with their 70 sacrifices. Thinke how that inchanting cup of fornications preuailes ouer their besotted soules; and you will say they are not lesse then madde. Come you into their Temples, and behold their Pageants, and histrionicall gestures, bowings, mowings, windings, and turnings; together with their seruice in an vnknowne language, and (like a deafe man, that sees men dancing, when hee heares no musicke) you would iudge them madde. Behold the masse-Priest with his baked god, towzing tossing, and dandling it, to and fro, vpward and downward, forward and backward, till at last, the iest turning into earnest, he choppes it into his mouth at one bitte; whiles all stand gaping with admiration; Spectatum admissi, risum tencatis amici? would you not thinke them ridiculously madde? But no wonder if they runne madde; that haue drunke that poyson. Many volumes haue beene spent in the discouery of their madnesse; I doe but touch it, lest I seeme to write Iliads after our learned Homers.

Surely Mad-men are dangerous without restraint. Papists are ready instruments of commotion, peruersion, treason.

Author: Adams, Thomas, fl. 1612-1653.
Title: Mystical bedlam, or the vvorld of mad-men. By Tho: Adams
Date: 1615
Bibliographic name / number: STC (2nd ed.) / 124
No. of pages: [6], 82 p.
Copy from: Cambridge University Library
Reel position: STC / 818:01

 

David Irish, Practitioner in Physick, His Advice concerning Melancholy, Phrensie, and Madness.

The Melancholy Passion is a doating of Reason, occaSingle illegible letterioned by vain fear, procured by the prevalency of Single illegible letterhe Melancholy Humour: We divide this Disease into Melancholy Cephalick, and Hypocondriack.

A Cephalick is when the disorder has its Residence Single illegible letterbout the lower part of the Abdomen, the Brain is Single illegible letterhiefly affected, which being disturbed, Men frame Single illegible lettertrange Fancies, and monstrous Idea's of things; all Melancholy people are extraordinary fearful, sad, and Single illegible letternactive.

According to the order I have observed in diviSingle illegible lettering Melancholy, it remains that I now speak of that Single illegible letterhich is called Hypocondriack, which, for the most Single illegible letterart, renders those Afflicted therewith, more stupid Single illegible letterhan any other sort doth, insomuch that they are Single illegible letterany times depriv'd of all Sense and Motion: This Single illegible letterort proceeds from Flegm obstructing the Hypocondria Single illegible letternd Spleen.

Hypocrates asserts, that the Soul in this Distemper Illegible worddistinctly affected with the weightier matter withSingle illegible lettern, and so neglects the Bodies Motions, by reason of Single illegible letterhe Brains stupidity through the aforesaid Humour.

Now to know whether the perturbations rise Illegible wordthe Humour or not: The perturbations are takeSingle illegible letter commonly to rise of Melancholy, Cholar, Blood, Illegible wordFlegm, therefore we call Men of a hasty dispositioSingle illegible letter Cholerick, those of sad dispositions Melancholy, tho[...] of heavy and dull Flegmatick, others of merry anSingle illegible letter cheerful Sanguine.

Melancholy differs from Phrensie and Madness, tho[...] in some respects they are near a Kin, for they all disturb the Reason; they differ thus, a Phrensie has always a Burning Fever; those that are taken with thiSingle illegible letter Disease are so Mad, that they furiously fall upon anSingle illegible letter body, and it is strange and admirable they do noSingle illegible letter destroy themselves, so exorbitant is the Malady; and such was their Infirmity spoken of in the Scripture, Mat. 8.28.24. They spare not their Parents, nor [...]eir best Friends, but are often most of all invete[...]te against them, and 'tis no wonder, since they bid [...]fiance to self-Preservation (the oldest Principle of Single illegible letterature) that they often attempt to lay violent hands [...]on themselves, therefore great care ought to be [...]ken of them: They are usually Untractable, Talk[...]ve, with strange Gestures, as Jumping, Singing, Single illegible letterancing, and Antickly tossing their Heads, writhing [...]eir Bodies, and generally look Surly and Haughty, Illegible wordsometimes they will seem Mild.

The common symptoms which attend most Mad [...]ople, are constant Watchings, and a prodigious [...]rculean strength; they can endure the greatest Illegible word, Hungar and Stripes, without any sensible harm; Illegible wordsometimes Swear, Shout, and on a suddain make [...]ange Noises; they play Apish tricks, often pulling [...]eir own Hair, tearing their Cloaths, breaking their [...]ndows, &c. they are strong and never tired out, Illegible wordoften muttering something to themselves as if it Illegible wordabout great matters; they are sometimes too Single illegible lettererry, and often too Sad, they sometimes Laugh, and [...]etimes Cry, and are fearful where no fear ought Illegible wordbe, and on a suddain become hasty, frappish, angry, [...]sterous, breaking their Chains and Fetters, beating Illegible wordpieces Walls and Doors, nay, every thing that [...]nds in their reach to be sure goes to wrack when Illegible wordsurly Fit is upon them; tho' they sleep little Illegible wordor Night, yet are they incredibly strong; they Illegible wordvery turbulent in their Anger, showing much Illegible word, brawling, shouting, and frame dreadful Illegible wordby reason of the fiery strength of the Animal Illegible word, which darts vigorously thro' all the Pores of Illegible worddistempered Body; hence also it is that they endure the severest Cold (tho' stark Naked) withIllegible word the least concern: Some say they are not sensible of Cold, &c. because (as they imagine) the Soul is so bus[...] within, that it does not attend to what is of less concern without, neither do they scarce perce[...] any inconvenience by such things as much annoy others· sometimes they are as Sav[...]e as Wild Beasts, theiSingle illegible letter Eyes look stern, big, and attentive, and they are eve[...] contriving some Mischief, because the Animàl SpiriSingle illegible letter pass furiously through the Brain, by reason of whicSingle illegible letter they are sometimes so Mad as to reproach and Cur[...] themselves and others, at such times they ought Illegible wordbe Fetter'd.

Madness often derives its Origen from the extrSingle illegible lettervagant height of some Passion, such as Fear, Lo[...] Ambition, Covetuousness, Care, Study, &c. Helm[...] says, it proceeds from Agony, Fear, Wrath, En[...] Ambition, Love, Pride, great Study, Care, Shame, &c. The Mad people are frequently solicitous about MaSingle illegible letterters above their reach, or about business that no waSingle illegible letter concern them. Lastly, Some are prone to Vene[...] delighting much in Company, &c.

The Melancholy person walks in osbcure places, sad and heavy, oft museth, imagining and speaki[...] many ridiculous things, but usuallSingle illegible letter fixes upon Illegible wordtrifle; he will not be perswaded from what he fancie Single illegible letteror tho' he fancy himself a King, a Prince or Proph[...] or indeed any thing else, he will industriously im[...]tate the Person or Character he puts upon himse[...]. Some that are afflicted with Melancholy are weary Illegible wordtheir Lives, have ill thoughts, talk idly, or witho[...] any order or coherence; they also take pleasure Illegible wordSolitude, are subject to Weep, and are often tak[...] with a suddain dislike of what they formerly Illegible wordaffected; they are so jealous, that they think eve[...] body cheats and lays snares for them; they are afr[...] of being Poysoned, their sleep is but little, and Illegible word

Author: Irish, David.
Title: Levamen infirmi: or, cordial counsel to the sick and diseased Containing I. Advice concerning physick, and what a physician ought to be; with an account of the author's remedies, and how to take them. II. Concerning melancholy, frensie, and madness; in which, amongst other things, is shew'd, how far they differ from a conscience opprest with the sense of sin, and likewise how they differ among themselves. III. A miscellany of pious discourses, concerning the attributes of God; with ejaculations and prayers, according to scripture rule. Likewise an account of many things which have happen'd since the creation. To which are added several predictions of what may happen to the end of the world. The whole being enrich'd with physical, pious, moral & historical observations, delightful to read, & necessary to know. By D. Irish, practitioner in physick and surgery, now dwelling at Stoke, near Guilford in Surry, where he is ready to serve any person, to the utmost of his skill.
Date: 1700
Bibliographic name / number: Wing (2nd ed.) / I1036
No. of pages: [8], 127, [1] p.
Copy from: British Library
Reel position: Wing / 2187:21



Other resources:

http://www.mentalhealthworld.org/29ap.html
http://www1.nmha.org/about/history.cfm

http://www.seattle.wa.lwv.org/pubs/mentalhealth/lwvmhhistory2.html


http://www.nami.org/
The National Alliance of Mental Illness is a great website to poke around for information about different mental illnesses and treatments. It also has some cool links to other mental illness related topics which we won't talk get to talk about in our class.

http://www.mayoclinic.com/health/mental-illness/HQ01079
This Mayo Clinic site explores one doctor's way of defining mental illness. It addresses a few topics we have already discussed in class.

http://topics.nytimes.com/top/news/health/diseasesconditionsandhealthtopics/mentalhealthanddisorders/index.html?inline=nyt-classifier
This link gives access to a video about a family coping with a daughter's mental illness. The video reminds us of the profound effect mental illness has on the individual and their loved ones. I thought it was pretty interesting.



b.    Treatment

Presentation on treating mental illnesses

c.    Enhancement

The Adderall Advantage in NY Times 7/31/05

Presentation on recreational drugs

Pharmacological Manipulation of the Nervous System

d.    Court-ordered medication
Forced Medication of Legally Incompetent Prisoners: A Primer

4.         Law and neuroscience
a.    Lie detection
Presentation on lie detection

Are polygraph tests a hoax? I think it is... but maybe I'm lying... or just lying about lying...
http://www.antipolygraph.org/

Are emerging neurotechnologies an invasion of privacy?
http://www.bioethics.upenn.edu/pdf/wolpe_emergingneurotech.pdf

Here's a short article from the University of Pennsylvania's Neuroethics  Program which raises some of the fundamental issues at stake when considering neuroscience and the law.

http://neuroethics.upenn.edu/responsibility2.html

b. Behavioral genetics, crime & responsibility
Presentation on behavioral genetics and the law

Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. Role of genotype in the cycle of violence in maltreated children. Science. 2002 Aug 2;297(5582):851-4.

Bernet W, Vnencak-Jones CL, Farahany N, Montgomery SA (2007) Bad Nature, Bad Nurture, and Testimony regarding MAOA and SLC6A4 Genotyping at Murder Trials. Journal of Forensic Science. appearing Novermber 2007

5.         Neuroeconomics & Neuromarketing
Neuroeconomics by Kevin McCabe

Integrity in Marketing

Neuromarketing: Is it coming to a lab near you? PBS Frontline

The Stepford Kids BORN TO BUY: The Commercialized Child and the New Consumer Culture

Neuromarketing, from Commercial Alert  Click on the links to (1) "Pushing the Buy Button," by Clint Witchall, (2) "Playing with your mind: is neuromarketing research giving advertisers the keys to your decision-making?" by Dean Schabner

Using M.R.I.’s to See Politics on the Brain from Center for Cognitive Liberty & Ethics


6.         Consciousness

The Mystery of Consciousness By Steven Pinker in Time Magazine Friday, Jan. 19, 2007

Presentation on Dreams

7.         Beginning of life, genetic testing & eugenics

Stages of human development

The Consciometer: What if scientists could precisely measure when life begins and ends? in Slate





8.         Brain death

Presentation on definitions of brain death

The Terry Schiavo case.


9.         Intelligence

Presentation on Intelligence

Nature vs Nurture in Intelligence (From Wilderdom: a project in natural living & transformation) -- This is just a super cool site about the general nature vs. nurture
debate. If you only have time to do a little reading, this is definitely the site to look at.

Is Intelligence in the Genes? Study Shows Gene May Affect Intelligence but Also Affects Schizophrenia By Miranda Hitti  WebMD Medical News -- This site looks at intelligence from a more scientific perspective. It's short and sweet and explains one gene's influence on intelligence.

Intercourse and Intelligence on Gene Expression posted by Jason Malloy -- This site discusses the relationship between intelligence and sex.  I found it interesting to see which major had the highest percentage of virgins and which had the lowest.  It was worth the read just to find out that only 65% of MIT GRADUATE students have had sex.  Overall, just pretty amusing.

10.         Artificial Intelligence

The Nature, Importance, and Difficulty of Machine Ethics by James H. Moor

Robotics and Intelligent Systems in Support of Society by Raj Reddy

This is an interesting link, if you want to check it out.  We'll be talking about it more in class:
http://discovermagazine.com/2007/brain/i-chat-therefore-i-am

Moravec, Hans.  When will computer hardware match the human brain? Journal of Evolution and Technology.  1998.  Vol. 1

Asimov's Laws of Robotics: Implications for Information Technology by Roger Clarke.  Published in two parts, in IEEE Computer 26,12 (December 1993) pp.53-61 and 27,1 (January 1994), pp.57-66

Man and the Machines: It's time to start thinking about how we might grant legal rights to computers. by Benjamin Soskis in Legal Affairs

Top 500 supercomputers -- The TOP500 project was started in 1993 to provide a reliable basis for tracking and detecting trends in high-performance computing. Twice a year, a list of the sites operating the 500 most powerful computer systems is assembled and released. The best performance on the Linpack benchmark is used as performance measure for ranking the computer systems. The list contains a variety of information including the system specifications and its major application areas.

The Blue Brain Project -- June 6, 2005 – IBM and The Ecole Polytechnique Fédérale de Lausanne (EPFL) are today announcing a major joint research initiative – nicknamed the Blue Brain Project – to take brain research to a new level.  Over the next two years scientists from both organizations will work together using the huge computational capacity of IBM’s eServer Blue Gene supercomputer to create a detailed model of the circuitry in the neocortex – the largest and most complex part of the human brain. By expanding the project to model other areas of the brain, scientists hope to eventually build an accurate, computer-based model of the entire brain.

PBS documentary concerning the DARPA autonomous land vehicle effort

11. Cloning

On Dolly the cloned sheep

12. Sexuality

Here are a LOT of articles about sexuality and gender.  Please read the starred articles.  They are all short and really interesting. The rest of the articles are more scholarly, but they are worth considering if you have time.

***"Born Gay?"
<http://www.time.com/time/magazine/article/0,9171,978923,00.html>
Controversial article examining genetic basis for homosexuality.

"Is there a Gay Gene?"
<http://www.webmd.com/sex-relationships/news/20050128/is-there-gay-gene>
Not exactly.  This article is similar to the above article.  Feel free to skip it.

***"O Brother Where Art Thou? The Fraternal Birth-Order Effect on Male Sexual Orientation"
<http://www.pnas.org/cgi/content/full/103/28/10531>
This is really interesting.  Please read in full.

***"Gender Identity"
<http://www.merck.com/mmhe/sec07/ch104/ch104b.html>
Short and to the point article about gender.

***"The Gender Conundrum"
<http://www.time.com/time/magazine/article/0,9171,1682256,00.html>
READ THIS!!!  It is short and really interesting!

***"Yep, They're Gay"
<http://www.time.com/time/magazine/article/0,9171,1582336,00.html>
READ THIS!!!  Why did they clone Dolly?  Because all of the rams were gay!

***"Sheep study poses sexuality questions"
<http://news.bbc.co.uk/1/hi/health/2404109.stm>
Even more fun facts about gay sheep.

***"Central Park Zoo's Gay Penguins Ignite Debate"
<http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2004/02/07/MNG3N4RAV41.DTL>
And finally, gay penguins.

"Clarifying Basic Concepts: Conceptualizing Sexuality"
<http://links.jstor.org/sici?sici=0022-4499%28198905%2926%3A2%3C249%3ACBCCS%3E2.0.CO%3B2-6>
This article gives us a basic definition of sexuality.  Just get a basic idea of what he is saying(know the four components of sexuality and what they mean).

"Sexuality, Human Rights, and Health"
<http://links.jstor.org/sici?sici=1079-0969%282004%297%3A2%3C5%3ASHRAH%3E2.0.CO%3B2-N>
This article presents some of the key policy issues regarding sexuality.  Skim it if you are interested.

"The Chemistry of Desire"
<http://www.time.com/time/magazine/article/0,9171,993148-1,00.html>
Some ideas on the connection between chemicals and sex.

13. Social implications of neuroethics