Muscles, Proprioception & Spinal Cord
Mechanisms
Sep 4, 2009
And indeed one may very well compare the
nerves
of the machine which I am describing with the tubes of the machines of
these fountains, the muscles and tendons of the machine with the other
various engines and springs which serve to move these machines, and the
Animal Spirits, the source of which is the heart and of which the
ventricles
are the reservoirs, with the water which puts them in motion.
- Rene
Descartes
(1664) Treatise on Man
Muscles
- Muscles needed to move the body. A system of
coordinates and nomenclature has been developed to describe these
movements.
- History
- Descartes - muscle inflated by animal spirits
- Realized the nerves not hollow tubes...
- and realized that muscles did not increase volume during
contraction...
- but no adequate theory to replace until
- 1791, L. Galvani
- frog nerve-limb preparation contracted if nerve in contact
with two
different
metals (iron & copper). Also limb contracted when nerve in contact
with another freshly cut muscle. Thus, irritable tissue not only was
sensitive
to electricity, but it also produced it.
- 1848, E. du Bois-Reymond
- measured action potential
- early 1950s
- muscle contraction thought due to contraction of protein in
muscle
- 1954, Hugh Huxley & Andrew Huxley proposed sliding
filament
theory
- Molecular
biology
of muscle contraction
- muscle contracts when myosin filaments heads attach to actin
filaments
and change shape which causes movement of the fibers relative to one
another.
myosin detaches, reverts to original shape and reattaches to actin
again.
- other molecules - tropomyosin and troponin - regulate whether
the
myosin
can attach to the actin
- depolarization of muscle fiber causes increase [Ca2+
] in
muscle
fiber cells; Ca2+ binds to troponin; receptor on actin for
myosin
becomes available; myosin binds to actin and changes shape; changed
conformation
of myosin moves actin relative to myosin filament; myosin detaches by
converting
ATP toADP + Pi in a process that requires Ca2+;
upon
detaching myosin converts back to original shape
- The length-tension
relation
- motor units
and
recruitment
- motor neuron + innervated fibers = motor unit
- Defined by Sherrington
- number of motor fibers / motor unit varies with effector: in
hand and
eye
there are fewer than 100 fibers per motor unit; in lower leg there are
1000 fibers per motor unit
- different kinds
of
muscle fibers
- same fibers in given motor unit
- fast (white meat) - fast twitch, easily fatigued, generate
greatest
force,
use glycolysis (anaerobic)
- slow (red meat) - slow twitch, not fatigable, longer
contraction time
but
generate 1-10% of force of fast fatigable, more mitochondria, more
oxidative
metabolism, high [myoglobin]
- motor neurons innervating fast/strong and slow/weak fibers
are
different
and matched in properties to the muscle fibers
- during normal action, motor units are recruited in orderly
fashion
- size principle
- first
motor units activated are the smallest and weakest; subsequent motor
units
are larger and stronger
- functional advantages of the size principle
- force is more easily regulated / modulated; by recruiting
motor units
in
order of increasing tension production, recruitment can stop when the
proper
amount of force is generated. amount of force added is proportional to
amount of force currently generated
- Production of joint angle
- neither force of muscle contraction nor length of muscle can be
determined
by neural activation
- because muscles act like springs, motor system controls
stiffness and
set-point
- but antagonist muscles activation must be considered too;
control of
opposing
muscles allows motor system to effectively produce and maintain desired
joint angles
- two mechanisms:
- reciprocal innervation - conserves energy, but to maintain
joint angle
the central motor system must anticipate loads accurately
- co-contraction - uses more energy, but increased joint
stiffness
prevents
movement by unexpected loads
- muscles contract slowly (10-100 ms) relative to speed of neural
input
(1-3
ms); to generate rapid, high forces motor system over-activates agonist
and then activates antagonist to brake movemen
Proprioception
- Sherrington - defined proprioceptors as sensory receptors for
stimuli
that
"are traceable to actions of the organism itself, and since the stimuli
to the receptors are delivered by the organism itself, the deep
receptors
may be termed proprioceptors..." (1906) Brain 29:467-482
- two essential properties
- the amount of muscle activity mobilized by proprioceptive
inputs is
small
- the adequate stimuli for proprioceptors arise from the actions
of the
organism
itself
- Behavioral effects of loss of proprioception
- e.g., The Disembodied Lady, Oliver Sacks
- Proprioception receptors
- Joint receptors - sensory endings in joint
- Some recordings from joint afferents report activity only at
extreme
angles,
but other recordings have found variation in activity through
intermediate
joint angles
- experiments in which input from different proprioceptive
sensors is
dissociated
indicates that joint (& cutaneous) information can be used to sense
joint angle -- the experiment involved posturing the hand with all but
middle digit extended and middle digit flexed. In this posture, the
distal
joint cannot be flexed. so no muscle spindle or tendon organ input, but
there are clear improvement in sensitivity when muscles engaged though
- artificial joint replacement does not prevent limb sense
- Cutaneous receptors - Movements and postures cause deformations
of skin
to which mechanoreceptors in skin are sensitive. damage to
mechanoreceptors
can seriously impair movement and posture maintenance
- muscles contain specialized receptors that sense different
features of
the state of the muscle
- muscle spindles respond to stretch of specialized intrafuscal
muscle
fibers
- golgi tendon organs are sensitive to changes in tension
- functional differences between spindles and tendon organs
derive from
their
different anatomical arrangements within muscle
- muscle spindles
- sensitive to muscle stretch
- 3 main components
- group of specialized muscle fibers - 2 main types: nuclear
chain fibers
& nuclear bag fibers (2 types: dynamic & static)
- sensory axons that terminate on muscle fibers
- primary ending - Ia sensory afferent, wrapped around
central region of
nuclear bag fiber and nuclear chain fiber
- secondary ending - group II afferent which terminates on
peripheral end
of muscle spindle
- motor axons that regulate sensitivity of spindle
- the primary and secondary endings of spindle afferents respond
differently
to phasic changes in length
- during muscle stretch or relaxation there are two phases -
early
dynamic
phase when length is changing and later static phase when length
reaches
endpoint.
- primary spindle afferents fires burst during dynamic phase
and less
during
static phase
- secondary afferent changes activity gradually, reaching new
steady
state
level during static phase
- primary endings activity proportional to speed of stretch, so
they can
signal speed of movement
- the central nervous system can control sensitivity of the muscle
spindles
through the gamma motor neurons
- the fusimotor system maintains spindle sensitivity during
muscle
contraction
- stimulate motor neurons alone results in pause in firing of
spindle
afferents
because muscle contracted and unloaded spindle
- stimulate and motor neurons simultaneously prevented pause in
spindle
Ia
afferent during contraction
- stimulation of motor cortex activates and motor neurons
together - "-
coactivation"
- two types of gamma motor neurons alter the responsiveness of
spindles
- dynamic motor neurons tune the spindle to signal more about
the dynamic
phase of stretch
- static motor neurons tune the spindle to signal more about
the static
phase
of stretch
- the relative amounts of static and dynamic activity is preset
according
to activity
- discharge of muscle spindle afferents produces stretch reflexes
- group Ia afferents make monosynaptic connections to motor
neurons
- stretch reflexes regulate muscle tone through negative feedback
Spinal
mechanisms
of motor coordination
- interneurons are the building blocks of spinal reflexes
- convergent and divergent connections are the basis of reflex
pathways
- networks of interneurons coordinate the timing of reflex
components
- inhibitory interneurons coordinate muscle action around a joint
- group Ia inhibitory interneurons coordinate opposing muscles
- balance between reciprocal inhibition and cocontraction
- Renshaw cells are part of a negative feedback loop to motor
neurons
- negative feedback stabilizes motor neuron activity, preventing
large
transient
changes
- cutaneous stimuli elicit complex reflexes that serve protective
and
postural
functions
- certain reflexes adapt to different body postures, e.g., frog
wiping reflex