Previous research on spatial memory indicated that memories of small layouts were orientation dependent (orientation specific) but that memories of large layouts were orientation independent (orientation free). Two experiments investigated the relation between layout size and orientation dependency. Participants learned a small or a large 4-point path (Experiment 1) or a large display of objects (Experiment 2) and then made judgments of relative direction from imagined headings that were either the same as or different from the single studied orientation. Judgments were faster and more accurate when the imagined heading was the same as the studied orientation (i.e., aligned) than when the imagined heading differed from the studied orientation (i.e., misaligned). This alignment effect was present for small and large layouts. These results indicate that location is encoded in an orientation-dependent manner regardless of layout size.